Description
Bupropion, commonly known by the brand name Wellbutrin, is a prescription medication primarily used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). It is also prescribed under the name Zyban to help patients quit smoking. Unlike many antidepressants that affect serotonin, bupropion primarily influences dopamine and norepinephrine, making it a unique treatment option.
How Bupropion Works
Bupropion is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI). It works by increasing the levels of norepinephrine and dopamine in the brain, two neurotransmitters that play a role in mood regulation, motivation, and reward pathways. This mechanism sets bupropion apart from SSRIs and SNRIs, offering patients an alternative when those medications are less effective.
Benefits of Bupropion (Wellbutrin)
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Treatment of depression – effective for major depressive disorder and SAD.
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Smoking cessation – helps reduce cravings and withdrawal symptoms.
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Weight neutrality – unlike some antidepressants, bupropion is less likely to cause weight gain.
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Energy and focus – may improve concentration and reduce fatigue.
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Lower risk of sexual side effects compared to SSRIs.
Dosage and Administration
Bupropion is available in several formulations:
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Immediate-release (IR): taken 2–3 times daily.
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Sustained-release (SR): taken twice daily.
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Extended-release (XL): taken once daily.
Typical adult dosage ranges from 150 mg to 450 mg per day, depending on the condition being treated. Always follow your doctor’s exact prescription and never exceed the recommended dose, as doing so increases the risk of seizures.
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