Description
Mysimba® is a prescription weight management medication that combines naltrexone hydrochloride and bupropion hydrochloride. It is designed to help adults with obesity or overweight (with related health risks) achieve sustainable weight loss when used alongside a reduced-calorie diet and increased physical activity.
This dual-action medicine works on the central nervous system, targeting appetite regulation and reward pathways to reduce cravings and improve control over eating habits.
Medical Uses of Mysimba
Mysimba is indicated for:
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Chronic weight management in adults with:
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A BMI ≥ 30 (obese), or
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A BMI ≥ 27 (overweight) with at least one weight-related condition, such as type 2 diabetes, high blood pressure, or dyslipidemia.
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Lifestyle support: Mysimba is not a stand-alone solution; it is part of a comprehensive weight loss plan that includes dietary changes, physical activity, and behavioral therapy.
How Mysimba Works
Mysimba combines two active ingredients:
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Naltrexone
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An opioid receptor antagonist traditionally used in treating alcohol and opioid dependence.
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In Mysimba, it helps regulate the reward system of the brain, reducing food cravings.
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Bupropion
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An antidepressant and smoking cessation aid that acts on dopamine and norepinephrine pathways.
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In this combination, it helps reduce appetite and food intake.
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Together, they act on the hypothalamus (hunger center) and mesolimbic reward system, supporting long-term weight management.
Dosage and Administration Mysimba
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Form: Film-coated tablets.
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Typical dosage: Gradually increased over several weeks to reduce side effects.
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Usually, two tablets twice daily is the maintenance dose.
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Administration: Taken by mouth with food.
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Treatment evaluation: If a patient has not lost at least 5% of body weight after 16 weeks, discontinuation should be considered.
⚠️ Dosage must be determined and supervised by a healthcare professional.
Benefits of Mysimba
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Supports clinically significant weight loss.
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Helps reduce food cravings and binge-eating behaviors.
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May improve blood sugar control in type 2 diabetes patients.
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May lower cardiometabolic risk factors (blood pressure, cholesterol).
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Provides a dual mechanism for appetite control and craving reduction.
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