Quetiapine (Seroquel)

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Quetiapine (brand name Seroquel) is an atypical antipsychotic medication widely prescribed for the treatment of mental health conditions such as schizophrenia, bipolar disorder, and major depressive disorder (MDD). It works by balancing neurotransmitters in the brain—primarily dopamine and serotonin—helping to reduce hallucinations, stabilize mood, and improve concentration.

Approved by the FDA in 1997, Quetiapine has become one of the most commonly used antipsychotic medications due to its versatility, effectiveness, and tolerability in both short-term and long-term psychiatric care.

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Description

Approved by the FDA in 1997, Quetiapine (Seroquel) has become one of the most commonly used antipsychotic medications due to its versatility, effectiveness, and tolerability in both short-term and long-term psychiatric care.


Medical Uses of Quetiapine (Seroquel)

Quetiapine is prescribed for several psychiatric conditions, either as a primary treatment or in combination with other medications:

  1. Schizophrenia

    • Reduces hallucinations, delusions, and disorganized thinking.

    • Improves focus and participation in daily activities.

  2. Bipolar Disorder

    • Effective for manic episodes (elevated mood, hyperactivity, impulsiveness).

    • Helps in depressive episodes (sadness, hopelessness, loss of interest).

    • Used as a maintenance treatment to prevent relapse.

  3. Major Depressive Disorder (MDD)

    • Often prescribed as an adjunct treatment to antidepressants.

    • Improves depressive symptoms when first-line therapies are insufficient.

  4. Off-Label Uses (under physician supervision)

    • Generalized Anxiety Disorder (GAD).

    • Post-Traumatic Stress Disorder (PTSD).

    • Insomnia (due to its sedative properties, though not a primary indication).


How Quetiapine Works (Mechanism of Action)

Quetiapine works by interacting with multiple neurotransmitter receptors in the brain:

  • Dopamine D2 receptor antagonist: Reduces psychotic symptoms such as delusions and hallucinations.

  • Serotonin 5-HT2A receptor antagonist: Enhances mood regulation and decreases anxiety.

  • Histamine and adrenergic receptor effects: Contribute to sedation, which may benefit patients with agitation or insomnia.

This multi-receptor action makes Quetiapine a broad-spectrum antipsychotic with both antipsychotic and mood-stabilizing effects.


Available Forms and Dosage Strengths

Quetiapine comes in two main formulations:

  1. Immediate-Release (IR) Tablets

    • Available in strengths: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, and 400 mg.

    • Usually taken 2–3 times daily.

  2. Extended-Release (XR) Tablets

    • Available in strengths: 50 mg, 150 mg, 200 mg, 300 mg, and 400 mg.

    • Designed for once-daily dosing for better compliance.

⚠️ Dosage varies depending on condition, patient age, and tolerance. Always follow a doctor’s prescription.

Additional information

Dosage

25mg, 50mg, 100mg, 200mg, 300mg

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