Description
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Mechanism of Action Zepbound (Tirzepatide):
Indications / Who Can Use Zepbound (Tirzepatide)
Zepbound is FDA-approved for:
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Adults with obesity (BMI ≥ 30 kg/m²), or
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Adults with overweight (BMI ≥ 27 kg/m²) who have weight-related medical conditions (e.g. type 2 diabetes, hypertension, dyslipidemia, or obstructive sleep apnea) .
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Also specifically approved for moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity.
It should not be used in children, with other tirzepatide products, or with other GLP-1 receptor agonists.
Dosage and Administration
Stage Dose Frequency Notes Initiation 2.5 mg once weekly Subcutaneous injection First 4 weeks, to improve tolerability. Titration Increase in 2.5 mg increments every ≥ 4 weeks Weekly Up to maintenance dose. Maintenance 5 mg, 10 mg, or 15 mg once weekly Weekly Best results (weight loss) seen at higher maintenance doses in studies. -
Available in single-use pens and single-dose vials.
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Injection sites: abdomen, thigh, or upper arm. Rotate injection site to avoid irritation.
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Use of Zepbound must be paired with a reduced-calorie diet and increased physical activity.
Clinical Trial / Efficacy Data
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In a 72-week trial of adults without diabetes, average weight loss was approx 15.0% at 5 mg, 19.5% at 10 mg, and 20.9% at 15 mg doses, compared to ~3.1% for placebo.
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Similar substantial weight loss observed in people with type 2 diabetes.
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In people with OSA, significant improvement in sleep apnea severity was seen, with many shifting to mild or no OSA after treatment.
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Reviews
There are no reviews yet.