Description
Biktarvy is a fixed-dose combination antiretroviral medication that includes:
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Bictegravir (BIC) – an integrase strand transfer inhibitor (INSTI) that blocks the integration of viral DNA into human cells.
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Emtricitabine (FTC) – a nucleoside reverse transcriptase inhibitor (NRTI) that interferes with viral replication.
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Tenofovir alafenamide (TAF) – a prodrug of tenofovir, also an NRTI, designed for strong antiviral activity with fewer kidney and bone side effects compared to older formulations.
This 3-in-1 combination provides a complete HIV regimen without the need for additional medications.
Approved Uses of Biktarvy
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Treatment of HIV-1 infection in adults and children weighing ≥14 kg
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For patients newly diagnosed with HIV or those switching from another regimen if they have no known resistance to the components
How Biktarvy Works
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Bictegravir stops the HIV enzyme integrase from inserting viral DNA into host cells.
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Emtricitabine and Tenofovir alafenamide block reverse transcriptase, an enzyme HIV needs to copy its RNA into DNA.
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Together, these mechanisms suppress viral replication, reduce viral load to undetectable levels, and help maintain healthy immune function.
Benefits of Biktarvy
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Single-tablet regimen – simplifies treatment with one pill per day.
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High barrier to resistance – especially due to bictegravir.
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Effective across diverse patient populations, including those with high baseline viral loads.
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Fewer kidney and bone complications compared to older tenofovir-based therapies.
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Well-tolerated with a favorable safety profile in most patients.
Reviews
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