Description
What is the Jardiance Family?
Jardiance family consists of:
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Jardiance (empagliflozin 10 mg and 25 mg) – Used primarily for type 2 diabetes management.
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Jardiance Duo (empagliflozin + metformin) – Combines empagliflozin with metformin for enhanced glycemic control.
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Jardiance for Heart Failure – Approved for heart failure with reduced ejection fraction (HFrEF), even in patients without diabetes.
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Jardiance for CKD – Used to slow chronic kidney disease progression and reduce kidney-related complications.
How Jardiance Family Works
Empagliflozin, the active ingredient, inhibits SGLT2 in the proximal renal tubules. This mechanism:
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Prevents glucose reabsorption in the kidneys
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Promotes urinary glucose excretion, reducing blood sugar
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Reduces blood pressure via osmotic diuresis
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Offers cardiovascular and renal protection beyond glucose control
Jardiance Family Clinical Benefits
1. Glycemic Control
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Reduces HbA1c levels in adults with type 2 diabetes
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Supports weight loss and lowers fasting blood glucose
2. Cardiovascular Benefits
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Reduces risk of cardiovascular death in patients with type 2 diabetes and established heart disease
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Improves heart failure outcomes, including hospitalization rates
3. Renal Protection
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Slows progression of chronic kidney disease
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Reduces risk of end-stage renal disease (ESRD) in diabetic and non-diabetic patients
4. Weight and Blood Pressure Benefits
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Promotes modest weight loss due to glucose excretion
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Lowers systolic blood pressure as a secondary benefit
Administration & Dosage
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Route: Oral, once daily, with or without food
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Standard doses:
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Jardiance: 10 mg or 25 mg
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Jardiance Duo: Varies based on metformin combination
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Adjustment: Dose may be modified for kidney function or concomitant medications.
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