Description
Liothyronine Sodium, commonly known as T3, is a synthetic form of the active thyroid hormone triiodothyronine. Medically, it’s prescribed for hypothyroidism — a condition where the thyroid doesn’t produce enough hormones, leading to slow metabolism, weight gain, and fatigue.
In fitness and bodybuilding, T3 is used off-label as a fat-burning compound due to its ability to dramatically increase metabolic rate. It’s often stacked with anabolic steroids or clenbuterol to preserve muscle mass during cutting phases.
🔍 Quick Facts About Liothyronine Sodium (T3)
| Property | Details |
|---|---|
| Drug Name | Liothyronine Sodium |
| Common Brand | Cytomel® |
| Class | Synthetic thyroid hormone (T3) |
| Primary Use | Hypothyroidism treatment |
| Bodybuilding Use | Fat burning / metabolic enhancement |
| Half-life | ~1 day (24 hours) |
| Administration | Oral tablet |
| Prescription Status | Prescription-only (most countries) |
⚙️ How Liothyronine Works (Mechanism of Action)
T3 is the active thyroid hormone that regulates metabolism at the cellular level. It increases the basal metabolic rate (BMR) by:
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Enhancing oxygen consumption
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Stimulating mitochondrial activity
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Increasing the rate of fat, protein, and carbohydrate metabolism
In bodybuilding, this translates to:
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Faster fat loss
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Increased energy
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Enhanced nutrient partitioning
🏋️♂️ Why Bodybuilders Use T3
🔥 Key Benefits of Liothyronine in Bodybuilding:
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Extreme fat-burning potential
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Ideal for contest prep or cutting cycles
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Preserves lean muscle (if used with anabolic steroids)
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Increases energy and alertness
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Enhances nutrient uptake and metabolic efficiency
⚠️ Without anabolic support, T3 may also burn muscle, making stacking with steroids (e.g. testosterone, trenbolone, Winstrol) common.
💊 T3 Dosage Guidelines (Bodybuilding Use)
Note: Always start low and taper both up and down to minimize thyroid suppression.
📈 Beginner T3 Cycle (Fat Loss):
| Week | Dose (mcg/day) |
|---|---|
| 1 | 25 mcg |
| 2 | 50 mcg |
| 3 | 50–75 mcg |
| 4 | 75–100 mcg |
| 5 | 50 mcg |
| 6 | 25 mcg (taper) |
⚠️ Max Dose for Bodybuilders:
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75–100 mcg/day is common
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Do not exceed 100 mcg/day unless under strict supervision
📉 Coming Off T3 (Important):
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Taper slowly (25 mcg reductions every few days)
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Allow natural thyroid function to recover
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Consider using T4 or thyroid support supplements post-cycle
🧪 T3 Stacking Options
| Goal | Stack T3 With |
|---|---|
| Preserve muscle | Testosterone, Trenbolone, Winstrol, Anavar |
| Enhanced fat loss | Clenbuterol, Yohimbine, ECA stack |
| Thyroid support | Selenium, zinc, ashwagandha, B vitamins |
📌 Never run T3 alone if your goal is to preserve muscle mass.
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