Description
Rybelsus semaglutide is an oral tablet form of semaglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist. It’s used alongside diet and exercise to help control blood sugar in adults with type 2 diabetes.
It is not approved for type 1 diabetes, nor is its safety established in children.
How It Works
Rybelsus semaglutide mimics the body’s natural GLP-1 hormone and reduces blood glucose through multiple synergistic mechanisms:
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Stimulates insulin release in response to elevated blood sugar
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Suppresses glucagon to reduce liver glucose production
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Slows gastric emptying, helping curb appetite
At the molecular level, semaglutide is structurally modified to resist DPP-4 degradation and prolong its activity via albumin binding. -
Available Strengths & Dosage Guidelines
Tablet strengths:
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3 mg (initiation)
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7 mg (maintenance)
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14 mg (higher maintenance)
Typical dosing schedule:
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Start with 3 mg once daily for 30 days (primarily for acclimatization, not for glycemic control)
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Increase to 7 mg daily (effective for blood sugar control)
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If needed after ≥30 days, can be increased to 14 mg daily
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Summary Snapshot
| Topic | Details |
|---|---|
| Type | Oral semaglutide (GLP-1 RA) for type 2 diabetes |
| Strengths | 3 mg (start), 7 mg (maintain), 14 mg (maximize) |
| Mechanism | Insulin release ↑, glucagon ↓, gastric emptying ↓ |
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